In 2011, A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma Tumors in Nude Mice BACKGROUND: This study looked at the combined effects of Temozolomide (TMZ) and cannabinoids THC and CBD on gliomas. TMZ is the standard treatment for glioblastoma multiforme (GBM). Researchers tested if adding cannabinoids could improve the treatment. Nude mice with …
In 2004, Antitumor Effects of Cannabidiol, a Nonpsychoactive Cannabinoid, on Human Glioma Cell Lines BACKGROUND: study to evaluate the in vitro antiproliferative ability of cannabidiol (CBD), a nonpsychoactive cannabinoid compound, on U87 and U373 human glioma cell lines. You can read the full article here => http://jpet.aspetjournals.org/content/308/3/838
In 2001, Neuroprotection by Δ9-Tetrahydrocannabinol, the Main Active Compound in Marijuana, against Ouabain-Induced In Vivo Excitotoxicity BACKGROUND: We show in a longitudinal magnetic resonance imaging study that Δ9-tetrahydrocannabinol (Δ9-THC), the main active compound in marijuana, reduces neuronal injury in neonatal rats injected intracerebrally with the Na+/K+-ATPase inhibitor ouabain to elicit excitotoxicity. You can read the full article here …
In 2001, Inhibition of Glioma Growth in Vivo by Selective Activation of the CB2 Cannabinoid Receptor BACKGROUND: Here we show that local administration of the selective CB2 agonist JWH-133 at 50 μg/day to Rag-2−/− mice induced a considerable regression of malignant tumors generated by inoculation of C6 glioma cells. Cannabinoid receptor expression was subsequently examined in biopsies from human astrocytomas You can …
in 2006, A pilot clinical study of Δ9-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme BACKGROUND: Here we report the first clinical study aimed at assessing cannabinoid antitumoral action, specifically a pilot phase I trial in which nine patients with recurrent glioblastoma multiforme were administered THC intratumoraly. You can read the full article here => https://www.nature.com/articles/6603236