In 2013, Cannabinoid CB₂ Receptors Regulate Central Sensitization and Pain Responses Associated with Osteoarthritis of the Knee Joint

BACKGROUND: The aim of this study was to determine whether activation of the CB₂ receptor attenuates pain behaviour in the MIA model of OA pain, and then to investigate the sites of action, and mechanisms by which, analgesic effects were produced.

You can read the full article here => https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840025/