n 2016, Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids

BACKGROUND: We hypothesized that proteotoxicity in nerve cells themselves may initiate an inflammatory response that can lead directly to their death and contribute to overall inflammation in the CNS. The following experiments identify the molecular basis of this inflammatory response using a human CNS nerve cell line that conditionally expresses Aβ.

You can read the full article here => http://www.nature.com/articles/npjamd201612--