In 2013, a study to evaluate if endocannabinoid system (ECS) is involved in the protective actions of minocycline after a TBI. Using a closed-head trauma mice model of 60 animals and 49 of them sustained TBI.
Background: Examined the involvement of CB1R and CB2R in the effects of minocycline on edema and neurological impairment. Data were analyzed using a 3-way analysis of variance, with factors being TBI, cannabinoid receptor antagonists, and minocycline treatment.
You can read the Abstract here =>https://www.ncbi.nlm.nih.gov/pubmed/23960212
You can read the full article here =>https://academic.oup.com/cercor/article/25/1/35/365149